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$49+ Cheap flights from Knoxville (TYS) to Chicago (CHI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/21. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — CHI
Jul 6 — Jul 131
Sun 7/6
Sun 7/13
1 adult, Economy
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Cheapflights Tip: The best prices from Knoxville McGhee Tyson to Chicago are usually found in September or October, booked 73 days in advance, depart on a Friday or Thursday and return on a Friday

Cheap flight deals from Knoxville to Chicago

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to Chicago (CHI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated July 1, 2025.

Round-trip from

$112
(Booking.com)

One-way from

$49
(Booking.com)

Popular in

April

Cheapest in

September

Average price

$271

Good round-trip deal

$79 or less

Good one-way deal

$58 or less
From Knoxville McGhee Tyson to Chicago (CHI)
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One-way flight from Knoxville McGhee Tyson to Chicago (CHI)
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Highest demand for flights based on searches. 9% potential increase in price ($24 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($5 potential savings vs. average RT price).
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Average for round-trip flights in July 2025
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Price to beat on a round-trip flight from Knoxville McGhee Tyson to Chicago (CHI).
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Price to beat on a one-way flight from Knoxville McGhee Tyson to Chicago (CHI).
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Find flight deals from Knoxville to Chicago

Cheapest flights from Knoxville to Chicago
Explore the most affordable flight options available from Knoxville to Chicago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 1, 2025.

This Booking.com deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/151:31 pmTYS - MDW
Nonstop1h 33mAllegiant Air
Mon 8/182:54 pmMDW - TYS
Nonstop1h 28mAllegiant Air
Deal found 7/1$112
This American Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/127:14 amTYS - ORD
Nonstop2h 04mAmerican Airlines
Mon 9/1511:56 amORD - TYS
Nonstop1h 47mAmerican Airlines
Deal found 6/30$189
This Mytrip deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/186:00 amTYS - ORD
1 stop11h 10mMultiple Airlines
Mon 8/256:56 amORD - TYS
1 stop15h 16mMultiple Airlines
Deal found 6/30$197
This United Airlines deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/225:45 amTYS - ORD
1 stop4h 51mUnited Airlines
Sat 8/307:47 pmORD - TYS
Nonstop1h 50mUnited Airlines
Deal found 6/30$199
This FlightHub deal was found by Cheapflights users on 6/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/168:22 pmTYS - MDW
1 stop27h 16mMultiple Airlines
Mon 10/2012:08 pmMDW - TYS
Nonstop1h 24mMultiple Airlines
Deal found 6/28$206
This Delta deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/156:14 pmTYS - MDW
1 stop4h 30mDelta
Sat 8/2310:31 amMDW - TYS
1 stop5h 38mDelta
Deal found 7/1$209
This Delta deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/266:08 pmTYS - ORD
1 stop4h 17mDelta
Mon 9/299:50 amORD - TYS
1 stop6h 13mDelta
Deal found 6/30$209
This Priceline deal was found by Cheapflights users on 6/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/105:25 pmTYS - ORD
1 stop7h 45mFrontier
Sun 7/135:40 amORD - TYS
1 stop9h 49mFrontier
Deal found 6/30$212
This Gotogate deal was found by Cheapflights users on 7/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/35:25 pmTYS - MDW
1 stop19h 15mFrontier
Sat 7/52:44 pmMDW - TYS
1 stop24h 45mFrontier
Deal found 7/1$350

Cheapflights Fare Finder

Customize your flight search to find flights from Knoxville to Chicago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
Use the filters below to find and compare flights from Knoxville to Chicago that are best for you.

Fly from

Knoxville

Fly to

Chicago

Route

Depart

Return

Price

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 8/15

1:31 pm-2:04 pm

Nonstop1h 33m

Chicago Midway

Mon 8/18

2:54 pm-5:22 pm

Nonstop1h 28m

$112

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 9/12

7:14 am-8:18 am

Nonstop2h 04m

Chicago O'Hare Intl

Mon 9/15

11:56 am-2:43 pm

Nonstop1h 47m

$189

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Mon 8/18

6:00 am-4:10 pm

1 stop11h 10m

Chicago O'Hare Intl

Mon 8/25

6:56 am-11:12 pm

1 stop15h 16m

$197

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 8/22

5:45 am-9:36 am

1 stop4h 51m

Chicago O'Hare Intl

Sat 8/30

7:47 pm-10:37 pm

Nonstop1h 50m

$199

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 10/16

8:22 pm-10:38 pm

1 stop27h 16m

Chicago Midway

Mon 10/20

12:08 pm-2:32 pm

Nonstop1h 24m

$206

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Fri 8/15

6:14 pm-9:44 pm

1 stop4h 30m

Chicago Midway

Sat 8/23

10:31 am-5:09 pm

1 stop5h 38m

$209

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Fri 9/26

6:08 pm-9:25 pm

1 stop4h 17m

Chicago O'Hare Intl

Mon 9/29

9:50 am-5:03 pm

1 stop6h 13m

$209

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Thu 10/16

8:22 pm-7:20 am

2 stops11h 58m

Chicago Midway

Mon 10/20

6:00 am-7:37 pm

2 stops12h 37m

$654

KnoxvilleChicago

TYS - MDW

TYSMDW

Knoxville McGhee Tyson

Mon 7/21

1:31 pm-2:04 pm

Nonstop1h 33m

$49

KnoxvilleChicago

TYS - ORD

TYSORD

Knoxville McGhee Tyson

Sun 8/10

5:25 pm-12:32 am

1 stop8h 07m

$102

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/30

Showing 1-10 of 16 results
1
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Best time to book a flight from Knoxville to Chicago

Have a flexible travel schedule? Discover the best time to fly to Chicago from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Chicago

How far ahead should I book a flight from Knoxville to Chicago?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to Chicago. Price data was last updated on June 27, 2025.

The best time to book flights from Knoxville to Chicago is 73 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Knoxville to Chicago?

Currently, August is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $245). Flying from Knoxville to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from TYS to CHI?

Find hourly flight availability from Knoxville to Chicago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated July 1, 2025.

It’s typically best to fly out from Knoxville to Chicago in the morning. Doing so could potentially save you 32% on the flight price compared to flying at noon, which is usually more expensive.

What is the cheapest day to fly from Knoxville to Chicago?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to Chicago. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Knoxville to Chicago flight should consider departing on Friday evenings when fares are most often at their lowest. Sunday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Knoxville to Chicago

Explore weekly flight availability from Knoxville to Chicago. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated July 1, 2025.

The most flights from TYS to CHI are scheduled on a Tuesday (31 on average). You will have fewer flight options on Sunday, which is when the least amount of flights are scheduled (10 on average).

Reviews of airlines servicing Chicago

Get insights into the airlines that provide service to Chicago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Chicago. Reviews last updated July 1, 2025.
Peruse reviews from past customers who have flown with Delta, United Airlines, and American Airlines from Knoxville to Chicago to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,973 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Delta
8.0
Very good
7,973 reviews
Delta
8.0
Very good
7,973 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
United Airlines
7.4
Good
8,853 reviews
Delta
8.0
Very good
7,973 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,973 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Allegiant Air
7.2
Good
710 reviews
Delta
8.0
Very good
7,973 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!
Frontier
5.9
Fair
3,290 reviews
Delta
8.0
Very good
7,973 reviews

Food

7.3

Overall

8.0

Boarding

8.2

Crew

8.5

Entertainment

7.9

Comfort

7.9

Reviews

1 / 20
10.0
Excellent

Kim,May 2025

PIH - SLC

This trip was fine even with delay I had plenty of time to get connection flight!

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Chicago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Chicago?

    If you book a flight to Chicago from Knoxville, you will be flying from McGhee Tyson, which is the city’s only airport. Knoxville McGhee Tyson (TYS) is located 11.3 mi from the center of Knoxville. There are 20 flights from McGhee Tyson to Chicago per day from 4 different airlines.

  • What are the cheapest airlines flying from Knoxville to Chicago round-trip?

    Our cheapest airline available from Knoxville to Chicago is Allegiant Air. Our recent data shows that you can find tickets from as low as $112 on this airline. Additional options worth looking into are American Airlines and United Airlines, starting at $189 and $199 round-trip. Allegiant Air is currently priced 54% below the average price you’ll pay for this route.

  • What are the cheapest airlines to fly from Knoxville to Chicago one-way?

    The cheapest airline one-way is Allegiant Air, with whom users have recently found tickets for as low as $49. However, be on the lookout for offers from Frontier and American Airlines, as they are both options that can get you from Knoxville to Chicago for a low price.

  • What are the most reliable airlines from Knoxville to Chicago?

    The top 3 most reliable airlines when flying from Knoxville to Chicago are Avianca (97%), Republic Airways (95%) and ANA (93%).

  • What are the cheapest flights from Knoxville to Chicago?

    On average you can expect to pay $1,657 for a flight from Knoxville to Chicago. The cheapest flight overall is $142 while the most popular route, (Knoxville McGhee Tyson - Chicago O'Hare Intl) is currently priced at $189.

  • Can I find deals for flights from Knoxville to Chicago that include hotel bookings?

    Yes. In addition to deals on Knoxville to Chicago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Chicago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Chicago.

  • Can I find deals for business class flights from Knoxville to Chicago?

    Yes. Cheapflights offers flight deals from Knoxville to Chicago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Knoxville to Chicago?

    Currently, August is the cheapest month in which you can book a flight from Knoxville to Chicago (average of $245). Flying from Knoxville to Chicago in March is currently the most expensive (average of $321). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Knoxville?

Book flights to Knoxville if you plan to visit one of these locations
Merrillville
Lansing
Benton Harbor
Porter
Hammond
Valparaiso
Chesterton

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Top 4 airlines flying from Knoxville to Chicago

Discover the top 4 airlines that operate flights from Knoxville to Chicago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$76Average$91FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$164Average$249FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$183Average$299FlexibilityNo cancel feeOn-time69%
DeltaCheapest$233Average$373FlexibilityNo cancel feeOn-timeN/A

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