HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Knoxville

$130+ Cheap flights from Panama City, FL to Knoxville (ECP - TYS)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
ECP — TYS
May 25 — Jun 11
Sun 5/25
Sun 6/1
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Panama City to Knoxville with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Panama City to Knoxville

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (ECP) to Knoxville (TYS). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$367
(American Airlines)

One-way from

$130
(American Airlines)

Popular in

August

Cheapest in

September

Average price

$497
Provider with most accurate pricing for Panama City NW Florida Beaches-Knoxville McGhee Tyson flight deals.
Search Deals
Provider most trusted by Cheapflights users for Panama City NW Florida Beaches-Knoxville McGhee Tyson flights.
Search Deals
From Panama City NW Florida Beaches to Knoxville McGhee Tyson
Search Deals
One-way flight from Panama City NW Florida Beaches to Knoxville McGhee Tyson
Search Deals
High demand for flights, 0% potential price rise
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in May 2025
Search Deals

Find flight deals from Panama City to Knoxville

Cheapest flights from Panama City to Knoxville
Explore the most affordable flight options available from Panama City to Knoxville. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 20, 2025.

This American Airlines deal was found by Cheapflights users on 5/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/138:24 amECP - TYS
1 stop6h 26mAmerican Airlines
Sun 7/208:22 pmTYS - ECP
1 stop4h 31mAmerican Airlines
Deal found 5/19$367
This Delta deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/126:00 amECP - TYS
1 stop2h 53mDelta
Sun 6/157:44 pmTYS - ECP
1 stop4h 37mDelta
Deal found 5/20$387
This United Airlines deal was found by Cheapflights users on 5/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/145:02 pmECP - TYS
1 stop25h 59mUnited Airlines
Sun 8/247:00 amTYS - ECP
2 stops14h 16mUnited Airlines
Deal found 5/20$552

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Knoxville that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2025.
Use the filters below to find and compare flights from Panama City to Knoxville that are best for you.

Fly from

Panama City

Fly to

Knoxville

Route

Depart

Return

Price

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sun 7/13

8:24 am-3:50 pm

1 stop6h 26m

Knoxville McGhee Tyson

Sun 7/20

8:22 pm-11:53 pm

1 stop4h 31m

$367

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 6/12

6:00 am-9:53 am

1 stop2h 53m

Knoxville McGhee Tyson

Sun 6/15

7:44 pm-11:21 pm

1 stop4h 37m

$387

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Thu 8/14

5:02 pm-8:01 pm

1 stop25h 59m

Knoxville McGhee Tyson

Sun 8/24

7:00 am-8:16 pm

2 stops14h 16m

$552

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Sat 11/1

7:12 pm-11:46 pm

1 stop3h 34m

$130

Panama CityKnoxville

ECP - TYS

ECPTYS

Panama City NW Florida Beaches

Fri 10/31

12:55 pm-1:18 pm

2 stops23h 23m

$285

Flights are sorted by cheapest round-trip flights first.

Deals found on 5/20

Compare providers for flights from Panama City to Knoxville

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Panama City to Knoxville in May.
ProviderPrice AccuracyTrust Score*
ExpediaPrice Accuracy1 starTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*2 stars
eDreamsPrice Accuracy3 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Panama City, Florida-Knoxville flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Panama City, Florida-Knoxville flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Panama City, Florida-Knoxville flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Panama City, Florida-Knoxville flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Panama City, Florida-Knoxville flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Panama City to Knoxville

Have a flexible travel schedule? Discover the best time to fly to Knoxville from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Knoxville

What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $295). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from ECP to TYS?

Find hourly flight availability from Panama City to Knoxville. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 20, 2025.

A simple way to save on the total cost of your ticket is to fly from Panama City, Florida to Knoxville in the evening. If you’re flexible enough to do this you can expect to save up to 19% on your trip compared to booking a flight in the afternoon.

Rainfall in Knoxville by month

Plan your trip to Knoxville by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Knoxville ranges from 2.7 - 4.8 inches per month. March is typically the wettest month, when rainfall can reach 4.8 in. October is typically the driest time to visit Knoxville when rainfall is around 2.7 in.

Temperature in Knoxville by month

Plan your trip to Knoxville by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Knoxville, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 78.8 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 39.2 F).

Reviews of airlines servicing Knoxville

Get insights into the airlines that provide service to Knoxville. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Knoxville. Reviews last updated May 20, 2025.
Delta
8.0
Very good
7,950 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,950 reviews
Delta
8.0
Very good
7,950 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,744 reviews
Delta
8.0
Very good
7,950 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,950 reviews

Comfort

7.9

Crew

8.5

Entertainment

7.9

Food

7.3

Overall

8.0

Boarding

8.2

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Knoxville. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines flying from Panama City, Florida to Knoxville round-trip?

    Our cheapest airline available from Panama City, Florida to Knoxville is American Airlines. Our recent data shows that you can find tickets from as low as $367 on this airline. Additional options worth looking into are Delta and United Airlines, starting at $387 and $552 round-trip. You may be able to fly from Panama City, Florida to Knoxville for 33% less than the average price by searching for these airlines.

  • Can I find deals for flights from Panama City to Knoxville that include hotel bookings?

    Yes. In addition to deals on Panama City to Knoxville flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Knoxville?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Knoxville.

  • Can I find deals for business class flights from Panama City to Knoxville?

    Yes. Cheapflights offers flight deals from Panama City to Knoxville by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City, Florida to Knoxville?

    Currently, January is the cheapest month in which you can book a flight from Panama City, Florida to Knoxville (average of $295). Flying from Panama City, Florida to Knoxville in March is currently the most expensive (average of $376). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Panama City?

Book flights to Panama City if you plan to visit one of these locations
Morristown
Cherokee
Corbin
Maryville
Oak Ridge
Alcoa
Murphy

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Panama City to Knoxville

See prices for flight routes from nearby airports that may be better suited for you.
Fort Lauderdale to Nashville flights
Orlando to Nashville flights
Miami to Nashville flights
Tampa to Nashville flights
West Palm Beach to Nashville flights
Fort Myers to Nashville flights
Jacksonville to Nashville flights
Fort Lauderdale to Knoxville flights
Orlando to Memphis flights
Miami to Memphis flights
Miami to Knoxville flights
Panama City to Nashville flights
Tampa to Knoxville flights
Orlando Sanford Intl to Knoxville flights
West Palm Beach to Knoxville flights
Orlando to Knoxville flights
Sarasota to Nashville flights
St Petersburg to Knoxville flights
Pensacola to Nashville flights
Tampa to Chattanooga flights
Fort Myers to Chattanooga flights
Fort Myers to Knoxville flights
West Palm Beach to Memphis flights
Sarasota to Knoxville flights
Tampa to Memphis flights
West Palm Beach to Chattanooga flights
Miami to Chattanooga flights
Jacksonville to Memphis flights
Orlando to Chattanooga flights
Gainesville to Nashville flights
Tampa to Blountville flights
Daytona Beach to Nashville flights
Tallahassee to Nashville flights
Fort Myers to Memphis flights
Jacksonville to Knoxville flights
Orlando to Blountville flights
Fort Lauderdale to Memphis flights
Key West to Nashville flights
Pensacola to Memphis flights
Sarasota to Chattanooga flights
Punta Gorda to Nashville flights
Melbourne to Nashville flights
Sarasota to Memphis flights
Gainesville to Memphis flights
West Palm Beach to Blountville flights
Melbourne to Memphis flights
Pensacola to Knoxville flights
Melbourne to Chattanooga flights
Daytona Beach to Knoxville flights

Top 2 airlines flying from Panama City to Knoxville

Discover the top 2 airlines that operate flights from Panama City to Knoxville. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$308Average$548FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$312Average$526FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
Site
Privacy Preferences©2025 Cheapflights
OSZAR »