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Santa Cruz de la Sierra

$289+ Cheap flights from Panama City (PTY) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/3. Fares are subject to change and may not be available on all flights or dates of travel.
PTY — VVI
Jun 30 — Jul 71
Mon 6/30
Mon 7/7
1 adult, Economy
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Cheapflights Tip: The best prices from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or November, booked 40 days in advance, depart on a Wednesday or Monday and return on a Monday

Cheap flight deals from Panama City to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Panama City (PTY) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 25, 2025.

Round-trip from

$566
(Avianca)

One-way from

$289
(Priceline)

Popular in

June

Cheapest in

April

Average price

$908
From Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl
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One-way flight from Panama City Tocumen Intl to Santa Cruz de la Sierra Viru Viru Intl
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Highest demand for flights based on searches. 12% potential increase in price ($73 potential increase over avg. RT price).
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Cheapest flight prices on average. 7% potential price decrease ($36 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Panama City to Santa Cruz de la Sierra

Cheapest flights from Panama City to Santa Cruz de la Sierra
Explore the most affordable flight options available from Panama City to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 25, 2025.

This Avianca deal was found by Cheapflights users on 6/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/311:05 amPTY - VVI
1 stop13h 45mAvianca
Sat 10/42:55 amVVI - PTY
1 stop14h 35mAvianca
Deal found 6/24$566
This Copa Airlines deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/104:17 pmPTY - VVI
Nonstop5h 02mCopa Airlines
Tue 8/2612:15 pmVVI - PTY
Nonstop4h 55mCopa Airlines
Deal found 6/23$593
This Mytrip deal was found by Cheapflights users on 6/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/75:25 pmPTY - VVI
1 stop7h 25mMultiple Airlines
Thu 8/1410:25 pmVVI - PTY
2 stops19h 05mMultiple Airlines
Deal found 6/23$799

Cheapflights Fare Finder

Customize your flight search to find flights from Panama City to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 25, 2025.
Use the filters below to find and compare flights from Panama City to Santa Cruz de la Sierra that are best for you.

Fly from

Panama City

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Fri 10/3

11:05 am-1:50 am

1 stop13h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sat 10/4

2:55 am-4:30 pm

1 stop14h 35m

$566

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Sun 8/10

4:17 pm-10:19 pm

Nonstop5h 02m

Santa Cruz de la Sierra Viru Viru Intl

Tue 8/26

12:15 pm-4:10 pm

Nonstop4h 55m

$593

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Thu 8/7

5:25 pm-1:50 am

1 stop7h 25m

Santa Cruz de la Sierra Viru Viru Intl

Thu 8/14

10:25 pm-4:30 pm

2 stops19h 05m

$799

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Wed 9/3

5:25 pm-1:50 am

1 stop7h 25m

$289

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Tue 9/2

3:20 am-4:35 am

2 stops24h 15m

$423

Panama CitySanta Cruz de la Sierra

PTY - VVI

PTYVVI

Panama City Tocumen Intl

Sun 7/6

9:43 pm-3:39 am

Nonstop4h 56m

$671

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/23

Best time to book a flight from Panama City to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Panama City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Panama City to Santa Cruz de la Sierra

How far ahead should I book a flight from Panama City to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Panama City to Santa Cruz de la Sierra. Price data was last updated on June 20, 2025.

The price you pay for your flight from Panama City to Santa Cruz de la Sierra may vary depending on when you book. For the best chance of a lower fare, look to book 40 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.

What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $597). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from PTY to VVI?

Find hourly flight availability from Panama City to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 25, 2025.

It’s optimal to fly from Panama City to Santa Cruz de la Sierra in the morning. By choosing this option you can save up to 4% on the cost of your flight, compared to a flight at noon.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated June 25, 2025.
Copa Airlines
7.5
Good
1,460 reviews

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.5

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Copa Airlines
7.5
Good
1,460 reviews
Copa Airlines
7.5
Good
1,460 reviews

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.5

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.
Avianca
6.7
Okay
2,353 reviews
Copa Airlines
7.5
Good
1,460 reviews

Comfort

7.4

Food

6.8

Crew

8.1

Overall

7.5

Boarding

7.8

Entertainment

6.8

Reviews

1 / 20
4.0
Okay

Paul,Jun 2025

PTY - MIA

The boarding process was terrible. No one followed the group numbers. Everyone got up and stood in the tiles upon landing. People kept getting up during the meal and beverage service to go the bathrooms, the crew had to go back and forth in the isles, the service took forever.

Related info for your journey

Find useful and relevant information for your journey from Panama City to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Panama City to Santa Cruz de la Sierra?

    To fly from Panama City to Santa Cruz de la Sierra, you need to book a flight from Tocumen Intl (PTY) to Viru Viru Intl (VVI). Nonstop flights to Santa Cruz de la Sierra Viru Viru Intl from Panama City Tocumen Intl take 27h 05m on average. When it comes time to book airfare, you have a few options: there is 1 outbound flight from Tocumen Intl to Viru Viru Intl offered by 2 different airlines.

  • What are the cheapest airlines flying from Panama City to Santa Cruz de la Sierra round-trip?

    Our cheapest airline available from Panama City to Santa Cruz de la Sierra is Avianca. Our recent data shows that you can find tickets from as low as $566 on this airline. An additional option worth looking into is Copa Airlines, starting at $593.

  • What are the cheapest flights from Panama City to Santa Cruz de la Sierra?

    Looking at all options, your cheapest flight can be booked for $592. While the most popular route (Panama City Tocumen Intl - Santa Cruz de la Sierra Viru Viru Intl) can be booked for $934 on average our data indicates $645 when flying from Panama City to Santa Cruz de la Sierra.

  • Can I find deals for flights from Panama City to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Panama City to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Panama City to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Panama City to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Panama City to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Panama City to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Panama City to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Panama City to Santa Cruz de la Sierra (average of $597). Flying from Panama City to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Santa Cruz de la Sierra car rentals
Santa Cruz de la Sierra Viru Viru Intl Airport car rentals
Cochabamba car rentals

Top 2 airlines flying from Panama City to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Panama City to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 25, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$321Average$358FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$405Average$571FlexibilityNo cancel feeOn-time70%

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