$112+ Cheap flights from Panama City (PTY) to South America
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/10. Fares are subject to change and may not be available on all flights or dates of travel.
Find cheap flights from Panama City to South America with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Panama City to South America
Keep the following information in mind while searching for Panama City to South America flight deals. Data was last updated June 5, 2025.
Round-trip from | $196 (Copa Airlines) |
|---|---|
One-way from | $112 (FlightHub) |
Popular in | January |
Cheapest in | March |
Average price | $588 |
Good round-trip deal | $99 or less |
Good one-way deal | $68 or less |
Find flight deals from Panama City to South America
Cheapest flights from Panama City to South AmericaExplore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2025.
Explore the most affordable flight options available from Panama City to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2025.
This Copa Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Copa Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Copa Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Avianca deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Priceline deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This FlightHub deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Avianca deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Copa Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Mytrip deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
This Avianca deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Cheapflights Fare Finder
Customize your flight search to find flights from Panama City to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2025.
Use the filters below to find and compare flights from Panama City to South America that are best for you.
Fly from
Fly to
Route
Depart
Return
Price
Panama CityBogotá
PTY - BOG
PTYBOG
Panama City Tocumen Intl
Thu 6/26
10:28 pm-12:06 am
Nonstop1h 38m
Bogotá El Dorado
Thu 7/10
4:59 am-6:49 am
Nonstop1h 50m
Panama CityMedellín
PTY - MDE
PTYMDE
Panama City Tocumen Intl
Sun 6/15
6:53 am-8:17 am
Nonstop1h 24m
Medellín Jose Maria Cordova Intl
Thu 6/19
8:49 am-10:16 am
Nonstop1h 27m
Panama CityCartagena
PTY - CTG
PTYCTG
Panama City Tocumen Intl
Thu 7/17
12:49 pm-2:04 pm
Nonstop1h 15m
Cartagena Rafael Nunez
Tue 7/29
9:22 am-10:41 am
Nonstop1h 19m
Panama CityBogotá
PTY - BOG
PTYBOG
Panama City Tocumen Intl
Tue 8/12
3:20 am-4:54 am
Nonstop1h 34m
Bogotá El Dorado
Sun 8/17
8:07 am-2:40 pm
2 stops6h 33m
Panama CityCartagena
PTY - CTG
PTYCTG
Panama City Tocumen Intl
Fri 7/4
3:40 pm-9:25 pm
1 stop5h 45m
Cartagena Rafael Nunez
Sun 7/6
6:40 pm-12:10 am
1 stop5h 30m
Panama CityMedellín
PTY - MDE
PTYMDE
Panama City Tocumen Intl
Fri 9/26
1:30 pm-2:00 pm
1 stop24h 30m
Medellín Jose Maria Cordova Intl
Sun 9/28
1:25 pm-2:40 pm
Nonstop1h 15m
Panama CityBarranquilla
PTY - BAQ
PTYBAQ
Panama City Tocumen Intl
Wed 6/18
11:20 am-6:10 pm
1 stop6h 50m
Barranquilla E Cortissoz
Thu 7/3
2:46 pm-9:10 pm
1 stop6h 24m
Panama CityBarranquilla
PTY - BAQ
PTYBAQ
Panama City Tocumen Intl
Wed 6/18
3:49 pm-5:09 pm
Nonstop1h 20m
Barranquilla E Cortissoz
Thu 7/3
6:24 pm-7:49 pm
Nonstop1h 25m
Panama CityCartagena
PTY - CTG
PTYCTG
Panama City Tocumen Intl
Thu 6/26
3:20 am-9:39 am
1 stop6h 19m
Cartagena Rafael Nunez
Mon 6/30
9:22 am-10:41 am
Nonstop1h 19m
Panama CityBogotá
PTY - BOG
PTYBOG
Panama City Tocumen Intl
Thu 7/24
3:20 am-4:54 am
Nonstop1h 34m
Bogotá El Dorado
Wed 7/30
8:35 am-10:25 am
Nonstop1h 50m
Best time to book a flight from Panama City to South America
Have a flexible travel schedule? Discover the best time to fly to South America from Panama City with our price prediction graph.
Cheapflights Insights
Everything you need to know about your flight from Panama City to South America
What is the cheapest month to book a flight from Panama City to South America?
Currently, May is the cheapest month in which you can book a flight from Panama City to South America (average of $359). Flying from Panama City to South America in December is currently the most expensive (average of $664). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from PTY to SA?
Find hourly flight availability from Panama City to South America. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 5, 2025.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Panama City to South America as you normally would.
Weekly flight availability from Panama City to South America
Explore weekly flight availability from Panama City to South America. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 5, 2025.
The most flights from PTY to 0SA are scheduled on a Thursday (15 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (9 on average).
Rainfall in South America by month
Plan your trip to South America by taking into account the average rainfall totals by month.
In terms of precipitation, rainfall in South America ranges from 0.8 - 9.4 inches per month. January is typically the wettest month, when rainfall can reach 9.4 in. July is typically the driest time to visit South America when rainfall is around 0.8 in.
Temperature in South America by month
Plan your trip to South America by taking into account the average temperature totals by month.
If weather is an important factor for your trip to South America, use this chart to help with planning. For those seeking warmer temperatures, January is the ideal time of year to visit, when temperatures reach an average of 73.4 F. Travelers looking to avoid the cold should look outside of June, when temperatures are typically at their lowest (around 62.6 F).
Reviews of airlines servicing South America
Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated June 5, 2025.
Food
Boarding
Crew
Overall
Entertainment
Comfort
Reviews
Mike,Feb 2025
NVT - LIS
Food
Boarding
Crew
Overall
Entertainment
Comfort
Reviews
Mike,Feb 2025
NVT - LIS
Food
Boarding
Crew
Overall
Entertainment
Comfort
Reviews
Mike,Feb 2025
NVT - LIS
Food
Boarding
Crew
Overall
Entertainment
Comfort
Reviews
Mike,Feb 2025
NVT - LIS
Food
Boarding
Crew
Overall
Entertainment
Comfort
Reviews
Mike,Feb 2025
NVT - LIS
Related info for your journey
Find useful and relevant information for your journey from Panama City to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes for Panama City to South America
See prices for flight routes from nearby airports that may be better suited for you.
Top 3 airlines flying from Panama City to South America
Discover the top 3 airlines that operate flights from Panama City to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2025.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$73 | Average$154 | FlexibilityNo cancel fee | On-time83% | |
| Cheapest$114 | Average$487 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$159 | Average$384 | FlexibilityNo cancel fee | On-time71% |